Colorectal cancer (CRC) is one of the major causes of cancer-related death in the world, and patient survival is highly dependent on tumor stage at the time of diagnosis. Due to the fact CRC is mostly asymptomatic until it progresses to advanced stages, the implementation of screening programs aimed at early detection has dramatically reduced the mortality of this disease in the United States. Future research is focused on the identification of new prognostic and predictive biomarkers for metastatic CRC, which has led to the development of novel targeted therapies and individualized treatment plans. In this Clinical Toolkit, you will find recent treatment guidelines, clinical trial data on novel therapies, and research on biomarkers that impact response to therapy. The integration of this knowledge will allow clinicians to optimally sequence and personalize treatment regimens in the management of colorectal cancer.